About Roche

A healthier future drives us to innovate, continuously advance science, and ensure access to healthcare for all. At Roche, we are building a world where people have more time with those they love.

We are advancing next-generation sequencing (NGS) by simplifying workflows, accelerating clinical research, and expanding access to genomic data. Our integrated solutions span from sample preparation to sequencing and bioinformatics—delivering a seamless “sample in, result out” experience.

Role Overview

The Systems Technology Group within Roche Sequencing Solutions is seeking a Senior Mechanical Engineer to design and develop advanced sequencing systems.

This is a hands-on, multidisciplinary role focused on solving complex mechanical challenges involving electro-mechanical, pneumatic, thermal, and fluidic systems.

Core Responsibilities

• Design and develop mechanical sub-systems including electro-mechanical, pneumatic, fluidic, and thermal components
• Collaborate cross-functionally with electrical, materials, and consumables teams
• Develop mechanisms for automated reagent and flow cell handling
• Design and implement thermal control systems
• Lead subsystem integration, verification, and troubleshooting
• Drive design reviews and resolve technical trade-offs
• Manage timelines and technical deliverables
• Create and maintain CAD models, drawings, and specifications
• Contribute to system architecture and technical strategy
• Present technical updates and engineering decisions to stakeholders

Required Qualifications

• PhD + 1 year, OR Master’s + 2 years, OR Bachelor’s + 4 years of relevant experience
• Strong expertise in mechanical and electro-mechanical system design
• Experience with thermal management and precision temperature control
• Hands-on experience with fluidics systems (pumps, valves, sensors, tubing)
• Proficiency in 3D CAD tools (e.g., SolidWorks)
• Experience with manufacturing processes (machining, injection molding, 3D printing)
• Strong troubleshooting skills across hardware, software, and chemistry interfaces
• Hands-on experience with machine shop tools and prototyping technologies
• Familiarity with Python, LabVIEW, or similar tools

Preferred Qualifications

• Experience with simulation tools (CFD, FEA)
• Background in NGS or genomics instrumentation
• Experience in regulated product development environments
• Strong communication and interpersonal skills
• Ability to manage multiple priorities effectively

Additional Information

• This is a fully on-site role in Santa Clara, CA
• No relocation assistance is provided
• No requirement for fluidics/microfluidics specialization, but life sciences instrumentation experience is preferred

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